Corise Taclimus Eye Ointment For Dogs & Cats

Corise Taclimus Eye Ointment | Tacrolimus 0.1% w/w | For Dogs & Cats | 5 g

Corise Taclimus Eye Ointment contains Tacrolimus 0.1% w/w, a topical immunosuppressive agent derived from Streptomyces tsukubaensis. This specialized ophthalmic ointment is primarily indicated for the management of Keratoconjunctivitis Sicca (KCS, also known as Dry Eye Syndrome) in dogs and cats, particularly in cases resistant to cyclosporine therapy.

Tacrolimus works by stimulating lacrimal gland function and preventing further tissue destruction in immune-mediated ocular conditions.

Composition (per gram)

• Tacrolimus: 0.1% w/w
• Sterile Ointment Base: q.s.

Primary Indications

For Ophthalmic Use:

• Keratoconjunctivitis Sicca (KCS/Dry Eye Syndrome) - especially in cases resistant to cyclosporine therapy
• Chronic Superficial Keratitis (Pannus)
• Immune-mediated ocular surface disorders

For Topical Dermatological Use: When prescribed by a veterinarian, may also be applied topically for:

• Atopic Dermatitis (localized areas)
• Miliary Dermatitis
• Inflammatory skin conditions around periocular areas
• Canine Atopic Dermatitis-associated infections

Mechanism of Action

Tacrolimus is a macrolide immunosuppressant that:

• Stimulates tear glands in animals with KCS (Dry Eye Syndrome)
• Prevents further destruction of lacrimal gland tissue in immune-mediated conditions
• Inhibits T-cell activation and reduces production of pro-inflammatory cytokines
• Suppresses immune-mediated responses that cause tissue damage in autoimmune ocular and skin conditions

This dual action makes it effective for both stimulating natural tear production and controlling inflammation in chronic ocular and dermatological disorders.

Dosage & Administration

For Ocular Use (Keratoconjunctivitis Sicca):

1. Apply a small amount (approximately rice grain size) to the affected eye(s) every 12 hours (twice daily)
2. Clean the affected eye area gently before application
3. Gently pull down the lower eyelid and apply the ointment to the inside of the eyelid
4. Allow the pet to blink several times to distribute the ointment
5. Prevent the pet from rubbing or pawing at the eye immediately after application

For Topical Dermatological Use:

1. Clean and dry the affected skin area before application
2. Apply a thin layer to affected areas twice daily (every 12 hours)
3. Gently massage into the skin until absorbed
4. Do not allow the pet to lick the treated area until completely dry (approximately 20-30 minutes)
5. Safe for application on face, neck, groin, and periocular areas

Treatment Duration:

• Continue treatment for the full duration prescribed by your veterinarian
• Some animals with immune-mediated KCS may require lifelong tacrolimus therapy
• Do not discontinue treatment without consulting your veterinarian, even if symptoms improve
• Regular veterinary follow-ups are essential to monitor treatment response

Important Safety Information

⚠️ Critical Warnings:

• Prescription Only: This medication must only be used under veterinary supervision
• Special Cases Only: Tacrolimus should be reserved for special cases and is not a first-line treatment
• Diabetic Pets: Consult your veterinarian if your pet is diabetic before using this medication
• Long-term Effects: Long-term effects and potential toxicities are not fully established
• Licking Prevention: Do not allow pets to lick the affected area after application until completely dry
• Lifelong Therapy: Animals with immune-mediated KCS may need tacrolimus therapy throughout their life
• Cyclosporine Alternative: Particularly useful in cases of cyclosporine resistance or intolerance

Contraindications:

• Do not use on open wounds or ulcerated skin
• Not for use in active viral eye infections (e.g., herpes keratitis)
• Not for use in active fungal eye infections
• Not for use in bacterial eye infections without concurrent antibiotic therapy
• Use with caution in pregnant or lactating animals (consult veterinarian)
• Do not use if your pet is allergic to tacrolimus or macrolide antibiotics

Potential Side Effects:

• Temporary mild stinging, burning, or irritation upon application
• Redness at application site (usually mild and transient)
• Occasional itching or sensitivity
• Rarely: systemic absorption may occur with extensive use

If any of the following occur, discontinue use and contact your veterinarian immediately:

• Severe eye pain or discharge
• Increased redness or swelling
• Vision changes or cloudiness
• Signs of systemic illness (lethargy, loss of appetite, vomiting)
• Allergic reactions (facial swelling, difficulty breathing, hives)

Precautions

• For veterinary use only - requires valid veterinary prescription
• Keep out of reach of children and pets
• Do not touch the tube tip to any surface (including eyes, skin, or hands) to prevent contamination
• Wear gloves when applying to prevent human exposure
• Wash hands thoroughly before and after application
• Avoid contact with eyes (for handlers) - if accidental contact occurs, rinse thoroughly with water
• Storage: Store below 25°C in a cool, dry place away from direct sunlight
• Do not freeze the ointment
• Check expiration date before use
• Dispose of properly according to local regulations for pharmaceutical waste
• Use within recommended period after opening (typically 28-30 days)

Drug Interactions

Inform your veterinarian if your pet is currently taking:

• Other immunosuppressive medications (e.g., cyclosporine, azathioprine, corticosteroids)
• Topical eye medications
• Systemic antibiotics or antifungals
• Any other prescription or over-the-counter medications

Concurrent use with other immunosuppressants may increase the risk of infections.

Key Features

Effective for Cyclosporine-Resistant Cases - Alternative therapy when cyclosporine fails
Dual Application - Suitable for both ophthalmic and dermatological use
Stimulates Natural Tear Production - Helps restore lacrimal gland function in KCS
Immunosuppressive Action - Controls immune-mediated inflammation
Macrolide-Based Formula - Derived from Streptomyces tsukubaensis
Sterile Ophthalmic Grade - Safe for direct eye application
Precision Applicator - Easy-to-use tube design for accurate dosing
Veterinary-Formulated - Specifically developed for companion animals

Disclaimer

This product is for veterinary use only and requires a valid veterinary prescription. The information provided is for educational purposes and does not replace professional veterinary advice, diagnosis, or treatment. Always consult your veterinarian for proper diagnosis, treatment planning, and monitoring of your pet's condition. Individual results may vary based on the underlying cause and severity of the condition.